I don't tolerate input lag well, so I stick to wired. "Wireless gaming" seems like a bit of an oxymoron to me. That said, I admit that I haven't tried a recent high-end wireless mouse, so I don't know how good they've gotten. Even if they feel indistinguishable, though, I'm personally not going to pay $100 for one when I can get the same responsiveness from a $15 wired one. I don't find the cord nearly unsightly enough to pay that much to eliminate it (and then have to worry about battery life). That's just me, though. I know that others prefer a more organized, minimalist desk.